Psalm 65:2, "You who hear prayer, to you all men will come," is a powerful statement about God's nature and accessibility. Let's break down its meaning:

"You who hear prayer..." This phrase highlights God's attentiveness and responsiveness to prayer. It emphasizes that God is not a distant, uninvolved deity, but rather one who actively listens to and considers the prayers of humanity. It speaks to God's compassion and willingness to engage with those who seek Him.

"...to you all men will come." This part suggests a universal draw to God, indicating that all people, regardless of background or status, will eventually turn to Him in prayer. This can be interpreted in a few ways:

In times of need: When faced with difficulties, trials, or existential questions, people often turn to prayer as a last resort or a source of hope and comfort.
In repentance and seeking forgiveness: Recognizing their shortcomings and seeking reconciliation, individuals may come to God in prayer to confess their sins and ask for mercy.
In worship and praise: Experiencing gratitude, awe, or a sense of connection with the divine, people may come to God in prayer to express their adoration and thankfulness.
Ultimate submission and recognition of God's sovereignty: Some interpretations see this as a future reality, either in this life or in the afterlife, where all people will ultimately acknowledge God's authority and come before Him.

In essence, the verse encapsulates the following key ideas:

God is accessible through prayer.
God listens to and responds to prayer.
There is a universal human need to connect with God.
Ultimately, all people will turn to God.

The verse offers hope and encouragement to those who pray, assuring them that their prayers are heard and that God is always available. It also suggests a future where humanity is united in its relationship with God.