Deuteronomy 28:6, "You shall be blessed when you come in, and you shall be blessed when you go out," is a powerful statement of comprehensive blessing. Let's break down what it means:

Comprehensive Blessing: The phrase "when you come in" and "when you go out" is a merism, a figure of speech where two opposite things are used to express totality. In this context, it means blessed in all aspects of life, at all times, and in all activities. There is no area of life left untouched by God's blessing.

Blessing Upon Arrival and Departure: "Come in" and "go out" can represent:
Daily activities: Blessed in your work, your leisure, your errands, your routines.
Major life events: Blessed in new beginnings, in endings, in transitions.
Home and community: Blessed both within your household and when interacting with the outside world.
Journeys: Blessed in your travels, both short and long.

Condition of Obedience: It is crucial to understand that this verse, like all of Deuteronomy 28, is part of a larger section outlining the blessings for obedience and the curses for disobedience to God's commands. This specific blessing is conditional. It is promised if the people of Israel diligently obey the Lord their God (Deuteronomy 28:1).

God's Favor and Provision: The blessing suggests God's favor, provision, protection, and guidance will be with the person in all they do. It implies success, well-being, and flourishing in every area of life.

In essence, Deuteronomy 28:6 promises that if you are obedient to God, you will experience his blessing consistently and comprehensively in every aspect of your life, from the mundane to the momentous. It paints a picture of a life lived under God's favor and provision.